Answers
In any case, normally your son's residency permit expires in one year (issued until 21 years old). He also cannot bring the wife here because he is a dependent and not the main applicant. What we propose is that you sell your property to your son and this makes him the main applicant. Then you are issued a residency permit as his parent and he can bring his wife too.
No, his wife cannot get a Golden Visa.
Children under 21 years of age, parents, spouse or partner with a cohabitation agreement concluded in Greece and in-laws of the main investor can benefit from the same investment of 250,000 euros and above and issue a permanent European residence permit too. So when your son becomes 21, one easy way is to transfer ownership of your real investment to your son, and your son, his spouse and you as parents could get Greek Golden Visas.
A residency permit for real estate owners is a new type of residency permit for third-country citizens. Beneficiaries of the right of entry and the permanent resident permit, which shall be renewed every five years, are: a) third-country citizens who own real estate property in Greece, either personally or through a legal entity of which they own the total of the company shares, provided the minimum value of the property is 250,000 euros; b) third-country citizen who has full ownership, ownership and possession of real estate in Greece, acquired through donation or parental benefit, of the minimum amount of 250,000 euros. The family members of the mentioned beneficiaries: spouses, the direct descendants of the spouses who are under the age of 21, the direct relatives of the spouses in the ascending line. Following the above provisions for the resident permit for property owners, the best solution to your request, if you have no other family members besides your spouse and your adult son who are currently enjoying the privilege of resident permit, is either the sale or donation/parental provision of the property to your son. In such a situation, your son becomes the main investor and, as his family members, you are granted the privilege of a residency permit his wife, his parents and his children in the future. Alternatively, your son could buy his own property with minimum value of 250,000 euros
Family members of the main investor are the direct unmarried descendants of the spouses, who are under the age of 21. After that, it is possible to acquire a renewal as an independent residence permit until they reach the age of 24 and then it is possible to renew it further according to pertinent immigration legislation. But since your son is going to be married, one of the above conditions cannot be fulfilled anymore. In such a case, if you don't have other children, already included in your application, and in order his wife to be also included as his family member, you should examine the option either to sell your property to your son or to transfer it through parental concession, after examining in advance the tax value of your property.